What an error! And the VirtualBox stopped loading anymore! This error:
myuser@srv ~ $ VBoxManage list vms VBoxManage: error: Failed to initialize COM! (hrc=NS_ERROR_FILE_TARGET_DOES_NOT_EXIST)
and here with the GIU, which offers a little bit more information about the error ID:
This error occurs despite the successfully loaded VirtualBox kernel modules!
The two errors are the same and hint there is a file missing (or files?)? In our case, after upgrading from virtualbox-bin (a binary package) to a virtualbox (a package, which actually builds the VirtualBox on the system) under Gentoo, but apparently, this error could occur to everyone, who tries to build yourself the VirtualBox bundle.
The solution is simple: just DO NOT CHANGE the installation path of the Virtualbox software, which by default is /opt/VirtualBox.
The path is hardcoded in the sources and cannot be changed! At present version 6.1.16, we could not find a build option to change it! Of course, the linking /opt/VirtualBox would do the trick to move the installation physically away from the /opt, but the path must be valid /opt/VirtualBox.
In Gentoo, the emerge default installation goes to “/usr/lib64/virtualbox“, so the maintainer of the package changed the path and Virtualbox stopped working! Or a user build it and install it in any other location should link the /opt/VirtualBox to the installation directory. For example, in Gentoo, the fix will be:
root@srv ~ $ ln -s /usr/lib64/virtualbox /opt/VirtualBox
root@srv ~ $ exit
myuser@srv ~ $ VBoxManage list vms
"gentoo_raw" {55346caf-04db-4d88-831a-111111111111}
"diskless" {44346caf-c952-5555-b8a3-111111111111}
"diskless-linux" {44346caf-424f-487f-ae8d-111111111111}
"centos7-netinstall" {44346caf-4e86-441b-8d1e-111111111111}
A simple link would bring back Virtualbox to live.
Bonus
Probably, there is a configuration file “xpti.dat” in two or more locations: ~/.config/VirtualBox/xpti.dat and ~/.VirtualBox/xpti.dat, which is generated on every start of a VirtualBox. In the file there are configuration lines like:
Keep on reading!