As the web grows and the technology advances the page size of the web sites also grows or just some times you might want to output a big chunk of data from your application server – PHP-FPM (but it could be any of another ruby, python, C, Django and more), for example.
Here is a fast configuration tip (note this is not the proxy-related warning!):

The default nginx buffers per CGI connection are too small

Here is what to do in your nginx configuration file:
First, look for a line “include /etc/nginx/fastcgi_params;” or similar and add or edit if they exist after this line:

        fastcgi_buffer_size 16k;
        fastcgi_buffers 32 16k;

Check out more for the buffers here http://nginx.org/en/docs/http/ngx_http_fastcgi_module.html#fastcgi_buffers
The warning should stop if it does not stop you can try raising them. It could consume more memory but could lower the IO usage of your disks and improve the performance of your site or whatever backend works!

Here is the warning in our nginx error logs. We got this warning when using php-fpm and the php output size was 325965 bytes (~320K).

2019/04/04 09:56:05 [warn] 24451#24451: *44269838 an upstream response is buffered to a temporary file /var/cache/nginx/fastcgi_temp/0/12/0019966120 while reading upstream, client: 10.10.10.10, server: srv17.srv.en, request: "GET /api/20140102/product HTTP/1.1", upstream: "fastcgi://127.0.0.1:9000", host: "srv17.srv.en"
2019/04/04 09:56:07 [warn] 24451#24451: *44269849 an upstream response is buffered to a temporary file /var/cache/nginx/fastcgi_temp/2/12/0019966122 while reading upstream, client: 10.10.10.11, server: srv17.srv.en, request: "GET /api/20140102/product HTTP/1.1", upstream: "fastcgi://127.0.0.1:9000", host: "srv17.srv.en"
2019/04/04 09:56:09 [warn] 24450#24450: *44269856 an upstream response is buffered to a temporary file /var/cache/nginx/fastcgi_temp/7/12/0019966127 while reading upstream, client: 10.10.10.12, server: srv17.srv.en, request: "GET /api/20140102/product HTTP/1.1", upstream: "fastcgi://127.0.0.1:9000", host: "srv17.srv.en"